IPA-3-loaded liposomes and methods of use thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11969396
APP PUB NO 20230110087A1
SERIAL NO

18047915

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Lipid-based delivery vehicles are provided. Nanoparticulate compositions typically including a p21 activated kinase (PAK) inhibitor and a lipid-based delivery vehicle are also provided. In preferred embodiments, the lipid-based delivery vehicle is a liposome, most preferably a sterically-stabilized liposome. Typically the lipid-based delivery vehicle includes one or more phospholipids, and optionally a sterol. In some embodiments, at least one of the phospholipids is PEGylated. In particular embodiments, the lipid-based delivery vehicle includes DSPC, DSPE-PEG2000, and cholesterol. In specific embodiments, the ratio of DSPC, DSPE-PEG, and cholesterol is 9:1:5. The nanoparticulate composition typically includes a PAK inhibitor, preferably a PAK-1 inhibitor such as IPA-3 or a derivative, prodrug, or pharmaceutically acceptable salt thereof. Methods of use, for example methods of treating cancer, particularly prostate and breast cancer by administering the composition to subjects in need thereof, are also provided.

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Patent Owner(s)

  • THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cummings, Brian S Athens, US 2 0
Najahi-Missaoui, Wided Athens, US 2 0
Rammohan, Shenoy Somanath Martinez, US 1 0

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