Method for correlating spectroscopic measurements with digital images of contrast enhanced tissue
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United States of America Patent
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Apr 20, 2010
Grant Date -
Apr 2, 2009
app pub date -
Dec 8, 2008
filing date -
Sep 27, 2005
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Abstract
A system and method of correlating Raman measurements with digital images of a sample so as to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.
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