Short synthetic route to taxol and taxol derivatives
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United States of America Patent
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Apr 16, 1996
Grant Date -
N/A
app pub date -
May 24, 1994
filing date -
May 24, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A short route to the total synthesis of the core skeleton of the taxol ring system is described. The same sequence of transformations can be carried out to make the 7-hydroxy series, and connect the additional carbon atoms required for the A-ring. The number of steps to the taxane skeleton is 13, making it the shortest route from readily available inexpensive starting materials.
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