Probes, microarray, primers, kit and applications for rapid detection of clinical ophthalmic microorganisms

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United States of America Patent

PATENT NO 11891670
APP PUB NO 20230008908A1
SERIAL NO

17929875

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Abstract

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Disclosed are probes, primers, a microarray, a kit and applications for rapid detection of clinical microorganism in ophthalmology, belonging to that technical field of clinical microorganism detection. The probes of that disclosure comprise probes for respectively detect Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus haemolyticus, Pseudomonas aeruginosa, Staphylococcus hominis, Serratia marcescens, Escherichia coli, Bacillus subtilis and Enterobacter cloacae. The disclosure also discloses primers for amplifying the target bacteria, which comprises primers which can amplify gene sequence fragments with intra-species homology of more than 95 percent (%) and inter-species homology of less than 75%. The disclosure also provides a method for synthesizing the hybridization probe on the microarray, a method for hybridization reaction and a method for scanning detection. The probes described in the present invention are highly specific and detects microorganisms in ophthalmic clinical samples with sufficient positivity, high accuracy and deliver diagnosis in a short period of time.

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Patent Owner(s)

Patent OwnerAddress
AFFILIATED EYE INSTITUTE OF SHANDONG FIRST MEDICAL UNIVERSITYNO 5 YAN'ERDAO ROAD SHANDONG QINGDAO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Huabo Qingdao, CN 9 34
Huang, Yusen Qingdao, CN 1 0
Li, Wenfeng Qingdao, CN 48 581
Liu, Qing Qingdao, CN 483 5041
Ren, Zhichao Qingdao, CN 1 0
Zhang, Bining Qingdao, CN 1 0

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