Hedgehog interacting proteins and uses related thereto
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United States of America Patent
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Sep 8, 2009
Grant Date -
Mar 8, 2007
app pub date -
May 22, 2006
filing date -
Sep 20, 1996
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Abstract
The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.
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