Acyl phosphonate inhibitors of .beta.-lactamases
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United States of America Patent
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Apr 17, 2007
Grant Date -
Jun 2, 2005
app pub date -
Jul 28, 2003
filing date -
Dec 24, 1997
priority date (Note) -
Expired
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Abstract
The invention provides novel .beta.-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic .beta.-lactamase inhibitors presently available, and which do not possess a .beta.-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as .beta.-lactamase inhibitors and as antibiotics.
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