Protease inhibitor conjugates and antibodies useful in immunoassay
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United States of America Patent
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Mar 15, 2011
Grant Date -
Jun 28, 2007
app pub date -
Jan 31, 2007
filing date -
Jul 13, 2001
priority date (Note) -
Expired
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Abstract
Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
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