Compositions comprising trimetrexate
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United States of America Patent
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Jun 10, 2003
Issued Date -
N/A
app pub date -
May 21, 2001
filing date -
Apr 26, 1999
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Abstract
This invention is directed to the novel composition of matter trimetrexate ascorbate, to compositions comprising trimetrexate ascorbate, and to compositions comprising trimetrexate and ascorbic acid. These compositions are useful in the treatment of diseases in mammals such as, but not limited to, cancer, bacterial and protozoal infections, malaria, psoriasis, and rheumatoid arthritis. The invention is further related to methods of stabilizing trimetrexate to degradation caused by heat, light, oxygen, or water.
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