Decarboxylative conjugate additions and applications thereof

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United States of America Patent

PATENT NO 11136349
APP PUB NO 20180179248A1
SERIAL NO

15579741

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Abstract

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Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF PRINCETON UNIVERSITY87 PROSPECT AVENUE PRINCETON NJ 08540

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
MacMillan, David Princeton, US 16 553
McCarver, Stefan Princeton, US 10 0
Novoa, Daniel New York, US 2 0

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