Keto acid salts and amine derivatives, and their use for preparing medicines
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United States of America Patent
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Aug 6, 2002
Grant Date -
N/A
app pub date -
Nov 13, 2000
filing date -
Mar 13, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention concerns the use of compounds of general formula (I): (X).sub.n1,Y,(Z).sub.n2 wherein n1 and n2 represent 0 or 1; X represents a natural amino acid, in particular an amino acid selected among ornithine, arginine, lysine, histidine or glutamine; Y represents a keto acid of formula (II): R--CO--COOH wherein R represents --CH.sub.3, --CH.sub.2 --CH.sub.3, --CH(CH.sub.3).sub.2, --CH(CH.sub.3)--CH.sub.2 --CH.sub.3, --CH.sub.2 --CH(CH.sub.3).sub.2, --CH.sub.2).sub.2 --COOH, --CH.sub.2).sub.3 --COOH; Z represents: a natural amino acid selected in particular among ornithine, arginine, lysine, histidine or glutamine; or a polyamine selected in particular among cadaverine, putrescine, spermidine, spermine or agmatine. Said compounds are useful for preparing a medicine for treating human or animal pathologies wherein are involved silent neurons, such as pathologies of the digestive tract, the bladder and the biliary ducts.
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