Gene sequence of recombinant human type II mitochondrial dynein-like GTPase and uses thereof

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United States of America Patent

PATENT NO 11459584
APP PUB NO 20210180086A1
SERIAL NO

17182903

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Abstract

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A gene sequence of recombinant human type II mitochondrial dynein-like GTPase having a nucleotide sequence shown in SEQ ID NO: 1 and uses thereof. A fusion nucleic acid comprising a nucleic acid encoding human type II mitochondrial dynein-like GTPase. A recombinant expression vector comprising the nucleic acid or a fusion nucleic acid. A transformant by which the nucleic acid or the fusion nucleic acid is introduced into a host. A non-human mammalian ADOA model based on the inactivation of the gene of type II mitochondrial dynein-like GTPase, which can effectively improve the pathological manifestations of ADOA using a recombinant expression vector encoding the human type II mitochondrial dynein-like GTPase. The expression level of the nucleic acid encoding the human type II mitochondrial dynein-like GTPase is higher, therefore, more human type II mitochondrial dynein-like GTPase can be obtained in the mitochondria. which can better treat eye diseases such as ADOA.

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Patent Owner(s)

  • WUHAN NEUROPHTH BIOTECHNOLOGY LIMITED COMPANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Li, Bin Hubei, CN 1121 9407

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