Method for identifying aQTL regions whose genotype modulates transcription factor activity

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United States of America Patent

PATENT NO 8483970
APP PUB NO 20100153018A1
SERIAL NO

12569794

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Abstract

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The disclosed subject matter is directed to genetic linkage methods for identifying genetic determinants of transcription factor activity. An inferred transcription factor activity profile is generated based on a nucleotide sequence-specific mathematical model of gene expression regulation. Genetic linkage analysis is performed to identify at least one genetic determinant linked to a specific transcription factor segregant based on the inferred transcription factor profile.

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Patent Owner(s)

  • THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bussemaker, Harmen J New York, US 2 4
Lee, Eunjee New York, US 1 2

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