Selection marker for cell transfection and protein production

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United States of America Patent

PATENT NO 11384342
APP PUB NO 20200199543A1
SERIAL NO

16727212

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Abstract

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The present invention is within the field of industrial protein production. The invention provides a novel expression system using dehydroorotate dehydrogenase (DHODH) as a selection marker in combination with leflunomide or a metabolite thereof, notably for use in mammalian cell lines. Expression vectors encoding DHODH, cell lines comprising said vectors and methods of producing recombinant proteins are also provided.

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Patent Owner(s)

  • SANOFI

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dumas, Bruno Paris, FR 17 36
Lounis, Nabil Paris, FR 3 7

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