Peptides and analogs for use in the treatment of oral mucositis

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11311598
APP PUB NO 20200323946A1
SERIAL NO

16379101

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Abstract

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Preclinical data obtained in models of chemotherapy-induced mucositis, radiation-induced mucositis, neutropenic infection and colitis indicate oral mucositis is a promising indication for Innate Defense Regulator (IDR) peptides. Preclinical efficacy results obtained with IDRs in mouse and hamster models of mucositis indicate that dosing every third day should be able to cover the mucositis “window” with seven to fourteen doses, depending on the duration of chemotherapy or radiation exposure. IDRs have also shown efficacy in mouse models of chemotherapy-induced oral and gastrointestinal mucositis, consistent with the response of the innate immune response to chemotherapy and/or radiation damage. IDRs are also effective at reducing bacterial burden and improve survival in the presence or absence of antibiotic treatment in various murine infection models.

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Patent Owner(s)

Patent OwnerAddress
SOLIGENIX INC29 EMMONS DRIVE SUITE B-10 PRINCETON NJ 08540

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abrams, Michael Custer, US 20 1486
Donini, Oreola Coquitlam, CA 12 12
Lee, Jackson Richmond, CA 6 69
North, John Comox, CA 7 401
Rozek, Annett Port Moody, CA 25 64

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