Succinate-binding polypeptides and use thereof

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United States of America Patent

PATENT NO 11332510
APP PUB NO 20200262889A1
SERIAL NO

16647945

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Abstract

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Polypeptides comprising an amino acid sequence of Slc26a6 or IRBIT comprising a mutation that increases NaDC-1 binding, stability of the polypeptide, stability of NaDC-1 complex or a combination thereof are provided. Polypeptides comprising an amino acid sequence of a mutant succinate receptor 1 (mutSUCNR1), comprising a mutation that increases succinate binding, stability of the polypeptide, stability of the mutSUCNR1-succinate complex or combinations thereof are also provided. Compositions comprising the polypeptides, nucleic acid molecules and vectors encoding the polypeptides, and methods of use of the polypeptides or compositions, specifically for treating succinate-associate diseases and conditions are also provided.

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Patent Owner(s)

  • B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN GURION UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ohana, Ehud Meitar, IL 1 0

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