Matrix-free MALDI mass spectrometry
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United States of America Patent
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Mar 9, 2010
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Sep 15, 2006
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Aug 25, 2006
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Abstract
Particles and monoliths are used for providing an ionized analyte for mass analysis by photon desorption having a size in the range of 0.5-100 μm, wherein the particles or monoliths are modified with a chemical compound capable of absorbing photons having a wave-length of at least 300 nm. The particles and monoliths allow the use of MALDI-MS for the high throughput screening of molecules having a molecular weight lower than 700 μ without interfering signals or with only a limited number of background signals.
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