Anti-PSMA antibodies, bispecific antigen-binding molecules that bind PSMA and CD3, and uses thereof

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United States of America Patent

PATENT NO 11155633
APP PUB NO 20190127480A1
SERIAL NO

16205917

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides antibodies that bind to prostate-specific membrane antigen (PSMA), bispecific antibodies that bind to PSMA and CD3, and methods of using the same. According to certain embodiments, the antibodies of the invention bind human PSMA with high affinity and bind CD3 to induce human T cell proliferation. The invention includes antibodies that bind PSMA and CD3 and induce T cell-mediated killing of PSMA-expressing tumor cells. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD3, and a second antigen-binding molecule that specifically binds human PSMA. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of prostate tumors expressing PSMA. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced targeted immune response is desired and/or therapeutically beneficial. For example, the antibodies of the invention are useful for the treatment of various cancers.

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Patent Owner(s)

  • REGENERAN PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crawford, Alison Dobbs Ferry, US 14 100
Dudgeon, Drew Union, US 6 12
Haber, Lauric Rye Brook, US 26 145
Kirshner, Jessica R New York, US 26 217
Rafique, Ashique Yonkers, US 24 773
Smith, Eric New York, US 232 3294
Thurston, Gavin Briarcliff Manor, US 100 1040

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