Compositions and methods for sensitizing and inhibiting growth of human tumor cells
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United States of America Patent
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Nov 18, 2008
Grant Date -
Dec 23, 2004
app pub date -
Jun 1, 2004
filing date -
Feb 19, 1998
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Abstract
Polynucleotides encoding carboxylesterase enzymes and polypeptides encoded by the polynucleotides which are capable of metabolizing a chemotherapeutic prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing tumor cells to a prodrug chemotherapeutic agent and inhibiting tumor growth with this enzyme are also provided. In addition, screening assay for identification of drugs activated by this enzyme are described.
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