Live attenuated viral vaccines for Eastern Equine Encephalitis virus
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United States of America Patent
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Sep 7, 2010
Grant Date -
Dec 16, 2004
app pub date -
May 26, 2004
filing date -
May 29, 2003
priority date (Note) -
Expired
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Abstract
Live attenuated Eastern Equine Encephalitis (EEE) vaccines that outperform the PE-6 vaccine in mice aerosol challenged with >1,000×LD50. Candidates include four furin-cleavage deletion mutants and one E3 deletion mutant. Each vaccine provided protection in birds against antigenically distinct North and South American strains of EEE. The PE-6 vaccine does not provide protection against South American EEEs. Animals inoculated with each of the vaccines of the invention developed neutralizing antibodies to EEE.
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