Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11220686
APP PUB NO 20200063129A1
SERIAL NO

16296530

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Abstract

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The present invention, at least in part, relates to the discovery of efficacious delivery of an RNAi agent (in preferred aspects of the invention, an siRNA) to a transplantable tissue. Organ rejection, transplantation-mediated transmission of viral infection, and triggering of apoptosis in transplanted tissues can each be minimized by the methods and compositions of the instant invention. The RNAi agent(s) of the instant invention can be delivered as “naked” molecules, or using liposomal and other modes of delivery, to transplantable tissues. Such delivery can occur via perfusion of the RNAi agent in solution through the vasculature of a whole or partial organ; or tissues including transplantable cells and cell lines may be bathed, injected or otherwise treated with RNAi agents. Preferred transplantable tissues include, for example, pancreas, liver, kidney, heart, lung, and all cells and cell lines derived from such tissues (e.g., pancreatic islet cells that may, e.g., be transplanted as a treated population).

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Patent Owner(s)

  • UNIVERSITY OF MASSACHUSETTS

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kowalik, Timothy F Princeton, US 15 106
Uknis, Marc E Chadds Ford, US 10 10

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