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Abstract

A method for treating AIDS, which comprises administering to a patient in need therefor a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR1## wherein R.sub.1 is an adenine, cytosine, guanine, thymidine, uracil, 5-substituted uracil, 5-substituted cytosine derivative, 2-fluoroadenine, 2.6-diaminopurine, 2-aminopurine, 6-thioguanine, or 7-deazaadenine group; R.sub.2 is H, or a OH group; R.sub.3 is a OH, O-acyl, O-palmitoyl group, or phosphates (as free acid, or its alkali, ammonium or alkyl ammonium salts), or any other precursor group for the hydroxyl group; or a physiologically acceptable salt thereof. Furthermore, the present invention comprises the new compounds: 2',3'-dideoxy-3'-fluoro-2-fluoroadenosine, 2',3'-dideoxy-3'-fluoro-6-thioguanosine, 2',3'-dideoxy-3'-fluoro-2,6-diaminopurineriboside, 2',3'-dideoxy-3'-fluoro-2-aminopurineriboside, 2',3'-dideoxy-3'-fluoro-5-aminomethyluridine, 2',3'-dideoxy-3'-fluoro-5-azidomethyluridine, and 2',3'-dideoxy-3'-fluoro-5-hydroxymethyluridine.

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First Claim