Targeted cytotoxic ratjadone derivatives and conjugates thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11236059
APP PUB NO 20200239426A1
SERIAL NO

16637257

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Abstract

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The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.

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Patent Owner(s)

  • HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Broenstrup, Mark Braunschweig, DE 15 40
Collisi, Wera Peine, DE 1 0
Fetz, Verena Berlin, DE 2 0
Huettel, Stephan Braunschweig, DE 2 0
Klahn, Philipp Braunschweig, DE 1 0
Mohr, Katrin I Braunschweig, DE 1 0
Tegge, Werner Braunschweig, DE 5 1

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