BRI constructs and methods of using

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7786283
APP PUB NO 20030221204A1
SERIAL NO

10185297

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides constructs that feature a nucleic acid molecule encoding an amino terminal region of a BRI polypeptide. A construct of the invention can further include a multiple cloning site joined to the 3′ end of the BRI nucleic acid molecule or a nucleic acid molecule encoding a heterologous polypeptide operably linked to the BRI nucleic acid molecule. The invention further provides methods of directing a heterologous polypeptide through the secretory pathway in a cell. Such methods utilize a construct of the invention that additionally contains a promoter that directs expression of the BRI and heterologous nucleic acid molecules. The construct is introduced into a cell and, following expression, the fusion protein is directed through the secretory pathway of the cell. In addition, a construct of the invention can be introduced into an animal to make the animal transgenic for the heterologous polypeptide.

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Patent Owner(s)

  • MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Das, Pritam Ponte Vedra Beach, US 18 88
Golde, Todd Eliot Ponte Vedra Beach, US 10 65
McGowan, Eileen M Jacksonville, US 2 7

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