Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions

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United States of America Patent

PATENT NO 8889709
SERIAL NO

12554584

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Abstract

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The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinizing polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.

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Patent Owner(s)

  • PROBIODRUG AG

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Almstetter, Michael Martinsried, DE 18 103
Cynis, Holger Halle/Saale, DE 20 86
Demuth, Hans-Ulrich Halle/Saale, DE 116 1888
Friedrich, Daniel Halle/Saale, DE 5 11
Gaertner, Ulf-Torsten Halle/Saale, DE 5 26
Gans, Kathrin Halle/Saale, DE 8 47
Hamann, Antje Dieskau, DE 3 5
Heiser, Ulrich Halle/Saale, DE 65 892
Hoffmann, Torsten Halle/Saale, DE 96 1769
Kehlen, Astrid Halle/Saale, DE 4 2
Rahfeld, Jens-Ulrich Lieskau, DE 28 109
Schilling, Stephan Halle/Saale, DE 51 591
Sommer, Robert Halle/Saale, DE 10 40
Thormann, Michael Martinsried, DE 25 136
Treml, Andreas Martinsreid, DE 20 99
Wermann, Michael Halle/Saale, DE 8 20

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