Methods of preparing T cells for T cell therapy

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United States of America Patent

PATENT NO 11723923
APP PUB NO 20200206265A1
SERIAL NO

16533109

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Abstract

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Provided herein are methods for delaying or inhibiting T cell maturation or differentiation in vitro for a T cell therapy, comprising contacting one or more T cells from a subject in need of a T cell therapy with an AKT inhibitor and at least one of exogenous Interleukin-7 (IL-7) and exogenous Interleukin-15 (IL-15), wherein the resulting T cells exhibit delayed maturation or differentiation. In some embodiments, the method further comprises administering the one or more T cells to a subject in need of a T cell therapy.

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Patent Owner(s)

  • KITE PHARMA, INC.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Perez, Arianne Santa Monica, US 5 27
Restifo, Nicholas P Bethesda, US 47 296
Rosenberg, Steven A Bethesda, US 192 3871
Sabatino, Marianna Santa Monica, US 6 268

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