Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure

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United States of America Patent

PATENT NO 9908841
SERIAL NO

15347354

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Abstract

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This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogs which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogs are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogs, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

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Patent Owner(s)

  • THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abernethy, Darrell R Annapolis, US 6 2
Beigi, Abhari Farideh M Durham, US 4 0
Chakir, Khalid Baltimore, US 6 2
Wainer, Irving William Washington, US 9 0
Xiao, Rui-Ping Baltimore, US 8 1
Zhu, Weizhong Philadelphia, US 16 26

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