Niclosamide formulations and methods of use

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United States of America Patent

PATENT NO 11771668
APP PUB NO 20210308079A1
SERIAL NO

17301444

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Abstract

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The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.

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Patent Owner(s)

  • FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Holmes, Eric Tallahassee, US 29 86
Ostrander, Gary Tallahassee, US 9 5

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