Anti-CD79B antibodies and immunoconjugates and methods of use

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United States of America Patent

PATENT NO 8545850
APP PUB NO 20110135667A1
SERIAL NO

12940435

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Abstract

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The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.

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Patent Owner(s)

  • GENENTECH, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Yvonne San Mateo, US 24 427
Dennis, Mark San Carlos, US 77 542
Dornan, David San Mateo, US 34 341
Elkins, Kristi San Francisco, US 24 480
Junutula, Jagath Reddy Fremont, US 41 1387
Polson, Andrew San Francisco, US 83 1535
Zheng, Bing Mountain View, US 70 1063

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