Substituted 3-alkyl and 3-alkenyl azetidine derivatives

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United States of America Patent

PATENT NO 7906503
APP PUB NO 20090069284A1
SERIAL NO

12288518

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

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Patent Owner(s)

  • MERCK SHARP & DOHME CORP.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baker, Robert K Cranford, US 31 268
Bao, Jianming Scotch Plains, US 53 262
Miao, Shouwu Edison, US 19 127
Rupprecht, Kathleen M Cranford, US 35 260

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