Neurodegenerative therapies

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United States of America Patent

PATENT NO 10231954
APP PUB NO 20170007583A1
SERIAL NO

15116296

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a compound of formula (I) wherein: Y represents a C or N atom which may be substituted or form a cyclic group with R″′ but may not be a quaternary C atom; R′ is —OR1, —CONH2, —CF3, F, —OH, —NO2, —CN or —OCOR1 in which R1, is C1-3 alkyl and each may be in the beta or gamma position; R″ is C1-3 alkyl or H; and R″′ is H or a group consisting of 1-12 non-hydrogen atoms and may be linear, branched and/or incorporate one or more cyclic groups, cyclic groups may be aromatic and/or heterocyclic and 2 or more cyclic groups may be linked or fused and each may be substituted; or a salt, hydrate or solvate of a compound of formula (I) for use in the treatment or prevention of a neurodegenerative disorder by inhibiting formation of neurofibrillary (tau) tangles and/or by inhibiting Dyrk 1A. The invention further relates to non-therapeutic uses of these compounds.

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Patent Owner(s)

  • LYTIX BIOPHARMA AS

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Leeson, Frederick A Tromso, NO 4 1
Stensen, Wenche Kvaloysletta, NO 14 31
Svendsen, John S Kvaloysletta, NO 4 1

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