Polymeric product of daunorubicin and glutaraldehyde
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United States of America Patent
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-
Nov 25, 1986
Grant Date -
N/A
app pub date -
Oct 26, 1983
filing date -
Feb 26, 1982
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
According to the invention, the antitumor agent such as daunorubicin and a well-defined quantity of a bifunctional crosslinking agent, such as glutaraldehyde, are brought together. A form of polymeric product is obtained, which is insoluble in aqueous media but which, on being resuspended in an aqueous medium in the absence of glutaraldehyde, gradually releases the antitumor agent in a soluble form, preserving its antitumor activity. Improvement of the conditions of treatment with antitumor agents.
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