Synthetic peptide inhibitors of Wnt pathway

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United States of America Patent

PATENT NO 9056891
APP PUB NO 20130273058A1
SERIAL NO

13917958

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Abstract

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A peptide or peptidomimetic comprising the amino acid sequence KKRLSVXLTSSLFR (SEQ ID NO: 1) or the inverse thereof, or comprising at least eight contiguous amino acids of helix C of β-catenin (SEQ ID NO: 41) or inverse thereof, wherein the peptide or peptidomimetic comprises a total of about 50 or fewer amino acids and inhibits the Wnt pathway, as well as a method of inhibiting the Wnt pathway in a cell, a method of treating or preventing a disease mediated by the Wnt pathway, and related compounds, compositions, and methods.

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Patent Owner(s)

  • NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Perantoni, Alan O Fairfield, US 4 11
Tanigawa, Shunsuke Frederick, US 3 3
Tarasova, Nadya I Frederick, US 13 52

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