Construct of self-circularization RNA

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United States of America Patent

PATENT NO 11939580
APP PUB NO 20230212574A1
SERIAL NO

18045860

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Abstract

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A self-circularization RNA construct that can be expressed in a DNA vector and simultaneously circularized through a self-targeting and splicing reaction to form a circRNA is disclosed. The circRNA can consist only of a gene of interest which can be a coding, non-coding, or a combination thereof. The gene of interest has the advantage of being able to rapidly express a peptide or protein. The formed circRNA has a circular structure and has a stable and high half-life because 5′ and 3′ ends are not exposed. Accordingly, functional RNA such as miRNA, anti-miRNA, siRNA, shRNA, aptamer, functional RNA for gene/RNA editing, ADAR (adenosine deaminase acting on the RNA)-recruiting RNA, mRNA vaccine, mRNA therapeutic agent, vaccine adjuvant, and CAR-T mRNA can be produced as a stable circRNA in cells.

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Patent Owner(s)

  • RZNOMICS INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Han, Seung Ryul Yongin-si, KR 3 0
Kim, Ji Hyun Seoul, KR 191 1282
Kim, Seongcheol Seongnam-si, KR 4 2
Lee, Kyung Hyun Seongnam-si, KR 2 1
Lee, Seong-Wook Seoul, KR 29 83

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