Inhibitors of Bruton's tyrosine kinase

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United States of America Patent

PATENT NO 8658653
SERIAL NO

13361726

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Abstract

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Disclosed herein are compounds, including compounds having the structure of Formula (A), (B), (C), and (D), as described in further detail herein, that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

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Patent Owner(s)

  • PHARMACYCLICS LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Honigberg, Lee San Francisco, US 86 9177
Pan, Zhengying Austin, US 57 6213
Verner, Erik Belmont, US 84 7535

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