Cysteine engineered antibodies and conjugates

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United States of America Patent

PATENT NO 11873330
APP PUB NO 20200339664A1
SERIAL NO

16787280

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Abstract

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Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.

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Patent Owner(s)

Patent OwnerAddress
GENENTECH INCCALIFORNIA USA CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bhakta, Sunil San Ramon, US 13 195
Junutula, Jagath R Fremont, US 30 525

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