Antibody for skewing sex ratio and methods of use thereof

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United States of America Patent

PATENT NO 11760793
SERIAL NO

17126677

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Abstract

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A purified antibody, or an antigen-binding fragment thereof, is provided that binds selectively to a protein specific to an X-chromosome of a mammalian sperm cell. The sperm cell protein includes an amino acid sequence set forth in SEQ ID NOs: 4 and 9-16. The antibody or antigen-binding fragment thereof may be derived by immunization of a host by an antigenic peptide composition including one or more natural or synthetic antigenic peptide sequences set forth as SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NOs: 4 and 9-16. The antibody finds utility in identifying an X-chromosome bearing sperm cell population, and in methods for skewing a sex ratio in mammals. Embodiments of the subject antibodies referred to herein as anti-GX1-E protein antibody and anti-GX1-M protein antibody have the ATCC Patent Deposit Designations PTA-125897 and PTA-125898, having been deposited on Apr. 2, 2019.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONKNOXVILLE TN 37996

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Edwards, J Lannett Sevierville, US 4 1
Rispoli, Louisa A Maynardville, US 4 1
Schrick, F Neal Sevierville, US 6 3

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