Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production
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United States of America Patent
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Jun 12, 2007
Grant Date -
May 12, 2005
app pub date -
Oct 4, 2004
filing date -
Apr 5, 2002
priority date (Note) -
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Abstract
Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in hematophagous insects generally, and production of Plasmodium species sporozoites in Anopheles species mosquitoes specifically; apparatuses and methods for the production of strains of hematophagous insects with desired properties such as hypoallergenicity or hyperinfectivity; methods of producing a parasite strain that is capable of withstanding cyropreservation at temperatures close to freezing; apparatuses and methods for the injection of an attenuated parasite vaccine; production of parasites and hematophagous insects that are free from contamination by unwanted biological agents; apparatuses for the reconstruction of complex parasitic life cycles aseptically to avoid the contamination of the parasite or the insect vector host with unwanted biological agents.
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