Triphosphate oligonucleotide modification reagents and uses thereof

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United States of America Patent

PATENT NO 6686461
SERIAL NO

09630627

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Abstract

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Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.

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Patent Owner(s)

  • SOLULINK BIOSCIENCES, INC.;TRILINK BIOTECHNOLOGIES, LLC;YOUNG, JR., WALTER R.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hogrefe, Richard I San Diego, CA 15 130
Schwartz, David A Encinitas, CA 102 2119

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