Method of inhibiting abnormal tau hyper phosphorylation in a cell
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United States of America Patent
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Sep 21, 1999
Issued Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Aug 9, 1991
priority date (Note) -
Expired
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Abstract
Novel TAU/neurofilament protein kinases, PK40 and PK36, are essentially purified and characterized. Novel immunoassays relating to the kinases and inhibitors for the kinases also are provided. Finally, DNA sequences encoding the kinases and cell lines relating to the kinases are provided. Methods of inhibiting abnormal tau HYPER PHOSPHORYLATION activity in a cell by contacting a cell with an inhibitor that binds to an ATP binding site of PK40, in an amount sufficient to inhibit said phosphorylating activity which is characteristic of abnormal tau HYPERPHOSPHORYLATION in Alzheimer's Disease is also provided.
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