Depth-resolved mid-infrared photothermal imaging of living cells and organisms with sub-micron spatial resolution

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United States of America Patent

PATENT NO 11940380
APP PUB NO 20230194421A1
SERIAL NO

18171910

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Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.

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  • PURDUE RESEARCH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheng, Ji-Xin Newton, US 52 168
Zhang, Delong Brighton, US 12 119

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