Salts of ranitidine and complexes of bismuth with carboxylic acids, and pharmaceutical compositions thereof
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United States of America Patent
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Apr 16, 1991
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N/A
app pub date -
Jul 17, 1989
filing date -
Jul 18, 1988
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Expired
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Abstract
The invention relates to salts formed between ranitidine and a complex of bismuth with a carboxylic acid, and solvates of such salts. Examples of suitable carboxylic acids are citric acid, tartaric acid and agaricic acid. The salts are useful in the treatment of gastrointestinal disorders, particularly gastroduodenal conditions. The salts show the antisecretory activity associated with ranitidine together with antibacterial activity against Campylobacter pylori and they also possess cytoprotective properties.
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