Apparatus and method for biomolecular analysis

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United States of America Patent

PATENT NO 11137343
SERIAL NO

17115017

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Abstract

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An apparatus, and method of operating the same, detects changes in biomass accumulating on a surface of a substrate while minimizing bulk effect. The apparatus includes a sensor substrate and two illumination sources. A first illumination source generates a first light having a first central wavelength. A second illumination source generates a second light having a second central wavelength different than the first wavelength. The first and second light are mixed to produce a combined light. An analyte solution is introduced to the sensor substrate. Incident light of the combined light is reflected from the sensor substrate to produce a signal. The signal is imaged with a camera to obtain a reflectance. Reflectance produced by the combined light is not affected by variations in the dielectric properties of the analyte solution. A biomass accumulated on the substrate is computed based on the reflectance.

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Patent Owner(s)

  • THE TRUSTEES OF BOSTON UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ünlü, M Selim Newton, US 12 4
Marn, Allison Marie Somerville, US 2 0
Yurdakul, Celalettin Brighton, US 7 2

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