Peptide fragments of tissue plasminogen activator
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United States of America Patent
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Aug 13, 1991
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N/A
app pub date -
Nov 6, 1989
filing date -
Nov 6, 1989
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Abstract
Novel peptide fragments of tissue plasminogen activator are described which have activity for inhibiting (a) the binding of tPA to human endothelial cells, and (b) the inactivation of tPA by plasminogen activator inhibitor-1 (PAI-1). Six peptides or peptide amides with these activities have the sequences, numbered according to the native protein: tPA (31-55), tPA (81-105), tPA (181-205), tPA (301-325), tPA (451-475, and tPA (531-555). It is hoped that small, synthesizeable molecules which prevent the inactivation of tPA by PAI-1 may provide a means for improving the efficacy of therapeutically administered tPA or for reducing the tendency of patients with elevated plasma PAI-1 concentrations to form fibrin clots.
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