Thioether-containing metal chelating compounds
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United States of America Patent
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Aug 3, 1999
Issued Date -
N/A
app pub date -
Jul 7, 1997
filing date -
Apr 2, 1993
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Expired
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Abstract
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have the formula (a) and (b), where A, A'=--SZ or Y, B=O or S, Y=(c), Z=H or a thiol protecting group, m=2 or 3, n=2 or 3, q=0 or 1, R=H or unsubstituted or substituted hydrocarbon and pharmaceutically acceptable salts, provided that at least one CR.sub.2 group represents CO and forms, together with an adjacent N atom; a --CONR-- amide group. ##STR1##
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