Hydroxamic acid derivative, method for producing same and use thereof

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United States of America Patent

PATENT NO 11827612
SERIAL NO

17421755

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Abstract

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The present disclosure is related to the field of enzyme inhibitors, and in particular to a hydroxamic acid derivative, a method for producing the same and use thereof. The hydroxamic acid group of the hydroxamic acid derivative can be chelated with zinc ions in the LpxC active area, and the derivative has a hydrophobic side chain which can bind to hydrophic channels in the enzyme LpxC. These guarantee that the hydroxamic acid derivative has good bactericidal activity against Gram-negative bacteria and low toxicity. The present disclosure also provides a method for producing the hydroxamic acid derivative, which requires a shorter reaction time and can provide the derivative with a high yield.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF MEDICINAL BIOTECHNOLOGY CHINESE ACADEMY OF MEDICAL SCIENCESINSTITUTE OF PHARMACEUTICAL BIOTECHNOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES BEIJING CITY BEIJING CITY 100050

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Du, Xiaonan Beijing, CN 5 0
Wang, Juxian Beijing, CN 2 0
Wang, Minghua Beijing, CN 48 648
Wang, Yucheng Beijing, CN 25 17
You, Xuefu Beijing, CN 3 1
Zhang, Guoning Beijing, CN 1 0
Zhu, Mei Beijing, CN 11 43

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