Organotypic DRG-peripheral nerve culture system

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United States of America

PATENT NO 11959903
APP PUB NO 20220003742A1
SERIAL NO

17478057

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.

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Patent Owner(s)

  • AXOGEN CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Deister, Curt Alachua, US 28 31

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