Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates

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United States of America Patent

PATENT NO 11759510
APP PUB NO 20220323564A1
SERIAL NO

17848466

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Abstract

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The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.

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Patent Owner(s)

  • MERCK SHARP & DOHME LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abeygunawardana, Chitrananda Ambler, US 24 63
Cui, Yadong Adam Norristown, US 20 48
Kosinski, Michael J Souderton, US 16 41
Musey, Luwy Kavuka Blue Bell, US 12 26
Porambo, Richard J Norristown, US 12 26

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