Methods of using muscle targeting complexes to deliver an oligonucleotide to a subject having facioscapulohumeral muscular dystrophy or a disease associated with muscle weakness

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United States of America Patent

PATENT NO 11787869
APP PUB NO 20230049450A1
SERIAL NO

17936483

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Abstract

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Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DUX4. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.

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Patent Owner(s)

  • DYNE THERAPEUTICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Qatanani, Mohammed T Waltham, US 58 851
Subramanian, Romesh R Framingham, US 64 865
Weeden, Timothy Waltham, US 61 871

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