Compositions and methods for modulation of LMNA expression

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United States of America Patent

PATENT NO 9856473
SERIAL NO

14315186

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Abstract

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Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.

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Patent Owner(s)

  • IONIS PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bennett, C Frank Carlsbad, US 408 7356
Crooke, Stanley T Carlsbad, US 153 5391
Dobie, Kenneth W Del Mar, US 319 3155
Freier, Susan M San Diego, US 510 6151
Vickers, Timothy Oceaside, US 21 339

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