FK506 derivative maintaining nerve regeneration activity without immunosuppressive activity, and use thereof

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United States of America Patent

PATENT NO 10226446
APP PUB NO 20170216254A1
SERIAL NO

15500353

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Abstract

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The present invention relates to an FK506 derivative which has reduced immunosuppressive activity but maintains nerve regeneration activity, a preparing method thereof, and a pharmaceutical composition comprising the same for preventing or treating nervous system diseases. A composition comprising 9-deoxo-prolyl-FK506, 31-O-demethyl-FK506, or 9-deoxo-31-O-demethyl-FK506 can promote nerve regeneration and has reduced immunosuppressive activity, thereby reducing side effects in the treatment of nervous system diseases.

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Patent Owner(s)

  • INTRON BIOTECHNOLOGY CO., LTD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ban, Yeon Hee Seoul, KR 3 4
Kwon, Ho Jeong Seoul, KR 16 9
Pramodb, Shinde Seoul, KR 2 2
Yoon, Yeo Joon Seoul, KR 9 14

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